Enteric resin (S100)
pH-dependent controlled release excipients, insoluble in water, and low permeability.
It can be used for sustained-release enteric coating.
Swell at pH≤6.8 and dissolve at pH >7.0 (colon targeting).
Chemical name:
Methyl methacrylate-methyl methacrylate copolymer (weight ratio ≈ 1:2)
中文名:
甲基丙烯酸共聚物B型
聚丙烯酸树脂III (CP2015)
English name:
Methacrylic Acid and Methyl Methacrylate Copolymer (1:2) (NF36)
Methacrylic Acid - Methyl Methacrylate Copolymer (1:2) (EP9.0)
Japanese name:
メタクリル酸コポリマーS（医薬品添加物規格）
CAS: 25086-15-1
UNII: 5KY68S2577
Packing specification: 10kg/barrel
Quality specification：CP、USP、EP、JPE
Physical properties
Properties: white granules or powder (S 100); slightly odor.
Mw: ≈125,000 g/mol
Tg: not available (pyrolysis)
Extensibility: very poor (plasticizer with 40~50% copolymer weight ratio)
Chemical properties
Anionic property, weakly acidic;
pH < 7.0 swell, permeable; pH > 7.0 dissolution (colon release).
